Hyper IgM Foundation Research Grant Funding

The following is a list of our past research grant recipients:

$100,000 –The Hyper IgM Foundation awarded a $100,000 research grant to Dr. Caroline Kuo, M.D., at the Regents of the University of California, Los Angeles (UCLA). This major seed funding will support pioneering research titled “Preclinical Development of a Prime Editing-Based Therapy for X-linked Hyper IgM,” aiming to accelerate the development of a safe, durable, and curative treatment for patients living with this severe inherited immunodeficiency.
$15,000 –The Hyper IgM Foundation awarded a $15,000 research grant to Dr. Rui Yang at Baylor College of Medicine towards a research project titled “An Atlas of Variant Effects in CD40 and CD40LG” to comprehensively assess the functional impact of all coding single-nucleotide variants (SNVs) in CD40LG and CD40 using a multiplexed assay of variant effects (MAVE) framework.

$75,000 –The Hyper IgM Foundation awarded a $75,000 research grant to Dr. Bruce Sullenger at Duke University, in collaboration with Dr. Suk See De Ravin at the National Institutes of Health. This seed funding will support the expansion of pioneering gene-editing research aimed at developing in vivo gene-editing approaches for the treatment of Hyper IgM Syndrome and related immune disorders.

$100,000 – The Hyper IgM Foundation awarded $100,000 to to Dr. Daniele Canarutto and Prof. Luigi Naldini at the San Raffaele Telethon Institute for Gene Therapy in Milan, Italy to support groundbreaking research into In-depth genome integrity characterization of CD4+ T-cells gene-edited at the CD40LG locus for the treatment of Hyper-IgM 1.

$30,000 – The Hyper IgM Foundation awarded $30,000 to Dr. Cheng Zhu at the Georgia Institute of Technology to support research into Dysmechanoregulation of CD40-CD40L interaction, signaling, and function by hyper IgM mutations.
$10,000 – The Hyper IgM Foundation awarded $10,000 to Dr. Junghee Shin, at Yale University School of Medicine research into Studying T-cell immune profiles at single-cell transcriptomic and proteomic levels in relation to CD40LG genetic variants and clinical manifestations.

$30,000 – The Hyper IgM Foundation awarded $30,000 to Dr. Shanmuganathan Chandrakasan at Emory University to support research into Comprehensive immune evaluation of carriers with CD40L deficiency.

$10,000 – The Hyper IgM Foundation awarded $10,000 to Dr. Maite de la Morena at Seattle Children’s Hospital to support the health-related quality of life study in pediatric and adult patients with X-linked Hyper IgM Syndrome. For more information see the press release .
$7,000 – The Hyper IgM Foundation budgeted $7,000 for Dr. Caroline Kuo’s research in connection with Site-Specific Gene Editing in the Treatment of X-Linked Hyper-IgM Syndrome.
$8,000 – The Hyper IgM Foundation budgeted $8,000 for a carrier study for X -linked Hyper IgM Syndrome carriers in conjunction with the Primary Immune Deficiency Treatment Consortium and the Wiskott–Aldrich Foundation.

$15,000 – The Hyper IgM Foundation awarded $15,000 to Dr. Antonio Condino-Neto at University of São Paulo, Brazil, to support research into Novel Immunopathological Mechanisms of X-Linked Hyper IgM Syndrome. For more information see the press release.
$5,000 – The Hyper IgM Foundation awarded $5,000 to Dr. Amit Rawat at Postgraduate Institute of Medical Education & Research in Chandigarh, India to support research into the exploration of the differentially expressed mRNA transcripts in activated CD4+ helper T cells of the X-linked Hyper lgM patients by RNA-Seq based whole mRNA transcriptome profiling. For more information see the press release .

$5,000 – The Hyper IgM Foundation awarded $5,000 to Dr. Caroline Kuo and the Regents of the University of California, Los Angeles, to support research in connection with Site-Specific Gene Editing in the Treatment of X-Linked Hyper-IgM Syndrome. For more information see the press release.