What is Hyper IgM Syndrome?

Hyper IgM Syndrome is a very rare, and potentially life-threatening genetic mutation that severely compromises the immune system. 

X-Linked Hyper IgM compromises the body’s ability to produce responses to pathogens such as bacteria and viruses. In a normal functioning immune system, a person will produce immunoglobulins or antibodies in response to an encounter with a pathogen such as bacteria or a virus. A person with Hyper IgM Syndrome, however, can only create very basic, primitive and largely ineffective IgM antibodies.

As a result of their inability to produce antibodies, patients with Hyper IgM are at significant risk for opportunistic and repeated infections. Combined with repeated infections over time, this defect in the T-cells poses a significantly increased risk for cancer.

The Hyper IgM Foundation

Hyper IgM Foundation, a non-profit organization, was founded in 2015 by dedicated parents, healthcare professionals and friends. Our mission is to improve the treatment, quality of life and the long term outlook for children and adults living with Hyper IgM through research, support, education, and advocacy to families and patients.

The Foundation’s Board of Directors is comprised of parents,  industry professionals and physicians committed to our mission improve the treatment, quality of life and the long term outlook for children and adults living with Hyper IgM through research, support, education, and advocacy to families and patients.